|
TMPY-01133
|
Latent TGF beta 1 Protein, Human, Recombinant (His)
CED,DPD1,transforming growth factor, beta ...
|
Human
|
HEK293 Cells
|
|
Latent TGF beta 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is A0A499FJK2. |
|
TMPJ-00249
|
TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
TGF-Beta-1,TGFB1
|
Human
|
HEK293 Cells
|
|
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family... |
|
TMPY-00500
|
Latent TGF beta 1 Protein, Mouse, Recombinant (His)
transforming growth factor, beta 1,TGF...
|
Mouse
|
HEK293 Cells
|
|
Latent TGF beta 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P04202. |
|
TMPY-00608
|
TGF beta 1 Protein, Rat/Mouse, Recombinant
transforming growth factor, beta 1,transfo...
|
Mouse,Rat
|
HEK293 Cells
|
|
TGF beta 1 Protein, Rat/Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.8 kDa. |
|
TMPY-03945
|
Latent TGF beta 1 Protein, Rat, Recombinant (His)
TGF β1,transforming growth factor, β1<...
|
Rat
|
HEK293 Cells
|
|
Latent TGF beta 1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P17246. |
|
TMPY-04211
|
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His)
transforming growth factor, β1,TGF β1<...
|
Cynomolgus
|
HEK293 Cells
|
|
Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa. |
|
TMPY-02638
|
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant
transforming growth factor, beta 1,转化生长因子,...
|
Human,Rhesus,Cynomolgus,Canine
|
CHO Cells
|
|
TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.8 kDa and the accession number is A0A499FJK2. |
|
TMPY-06247
|
TGF beta 3 Protein, Human, Recombinant (hFc)
TGF-beta 3,ARVD,TGF β3,TGF
|
Human
|
HEK293 Cells
|
|
TGF beta 3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.2 kDa and the accession number is P10600-1. |
|
TMPK-01243
|
GDF-15 Protein, Rat, Recombinant (His)
GDF-15,PDF,PTGF-beta,MIC-1
|
Rat
|
E. coli
|
|
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.68 kDa and the accession number is Q9Z0J6. |
|
TMPK-01246
|
GDF-15 Protein, Mouse, Recombinant (His)
MIC1,Placental TGF-beta,Placental...
|
Mouse
|
E. coli
|
|
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec... |
|
TMPJ-00771
|
TGF beta 1 Protein, Mouse/Rat, Recombinant
TGFB,TGFbeta,CEDLAP,TGF-...
|
Mouse,Rat
|
HEK293 Cells
|
|
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II)... |
|
TMPK-00305
|
TGFBR1 Protein, Human, Recombinant (mFc & Avi)
tbetaR-I,TGFβRI,TGFbetaR...
|
Human
|
HEK293 Cells
|
|
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. TGFBR1 Protein, Human, Recombinant (mFc & Avi) is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is P36897-1. |
|
TMPJ-00261
|
TGF beta 2 Protein, Mouse/Rat, Recombinant
transforming growth factor β-2,BSC-1 cell growth in...
|
Mouse,Rat
|
HEK293 Cells
|
|
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n... |
|
TMPJ-00258
|
TGF beta 2 Protein, Human, Recombinant
Glioblastoma-derived T-cell suppressor factor,TGF-β...
|
Human
|
HEK293 Cells
|
|
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be... |
|
TMPJ-00250
|
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
transforming growth factor β1,TGFβ,CED,
|
Human
|
HEK293 Cells
|
|
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with ... |
|
TMPY-05521
|
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated
TGFB,TGF β1,转化生长因子,TGF-<...
|
Human
|
HEK293 Cells
|
|
Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is A0A499FJK2. |
|
TMPY-05313
|
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated
transforming growth factor, beta 1,transfo...
|
Mouse
|
HEK293 Cells
|
|
Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P04202. |
|
TMPJ-00622
|
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)
转化生长因子,Transforming growth factor β-1,Latent TG...
|
Cynomolgus
|
HEK293 Cells
|
|
Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 11 and 35-45 KDa and the accession number is F7HCV5. |
|
TMPY-00229
|
Latent TGF beta 1 Protein, Canine, Recombinant (His)
transforming growth factor, β1,transforming growth ...
|
Canine
|
HEK293 Cells
|
|
Latent TGF beta 1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa. |
|
TMPJ-00772
|
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Transforming growth factor β-1,Latent TGF-...
|
Mouse
|
HEK293 Cells
|
|
Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weight is 13 and 35-45 KDa and the accession number is P04202. |
|
TMPK-01244
|
GDF-15 Protein, Mouse, Recombinant (hFc)
PTGFBPTGF-beta,PTGFB,PLA...
|
Mouse
|
HEK293 Cells
|
|
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec... |
|
TMPK-00197
|
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated
Placental TGF-β,GDF15,RG-1,MIC-
|
Human
|
HEK293 Cells
|
|
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am... |
|
TMPK-00665
|
GDF-15 Protein, Cynomolgus, Recombinant (His)
PTGFBPTGF-beta,PTGFBP
|
Cynomolgus
|
E. coli
|
|
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus... |
|
TMPK-01245
|
GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
RG-1,GDF15,Placental TGF-beta...
|
Mouse
|
HEK293 Cells
|
|
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am... |
|
TMPK-00663
|
GDF-15 Protein, Cynomolgus, Recombinant (hFc)
PTGF-β,GDF-15,NAG-1,PTGF...
|
Cynomolgus
|
HEK293 Cells
|
|
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus... |
|
TMPK-00198
|
GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
MIC-1,PTGFBPTGF-β,GDF15,...
|
Human
|
HEK293 Cells
|
|
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am... |
|
TMPK-00664
|
GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated
Placental TGF-beta,PTGFBPTGF<...
|
Cynomolgus
|
HEK293 Cells
|
|
Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am... |
|
TMPK-00196
|
GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated
NAG-1,Placental TGF-beta,PTGF...
|
Human
|
E. coli
|
|
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 15.19 kDa and the accession nu... |
|
TMPK-00569
|
GDF-15 Protein, Canine, Recombinant (His)
GDF15,MIC1,MIC-1,PLAB,GDF-1
|
Canine
|
E. coli
|
|
Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. GDF-15 Protein, Canine, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 13.12 kDa and the accession number is A0A8C0TNP6. |
|
TMPK-00306
|
TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated
TGFbetaRI,TGFBR1,ALK-5,S...
|
Human
|
HEK293 Cells
|
|
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is... |
|
TMPH-00305
|
TGF-beta 1 Protein, Bovine, Recombinant (His)
|
Bovine
|
E. coli
|
|
TGF-beta 1 Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 16.8 kDa and the accession number is P18341. |
|
TMPJ-01178
|
TGFBR1 Protein, Mouse, Recombinant (hFc)
ALK-5,ALK-5ALK5,TGFβRI,tβR-I,LDS1A,TGF...
|
Mouse
|
HEK293 Cells
|
|
TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models i... |
|
TMPH-00382
|
TGF-beta 1 Protein, Chicken, Recombinant (His & SUMO)
|
Chicken
|
E. coli
|
|
TGF-beta 1 Protein, Chicken, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.0 kDa and the accession number is P09531. |
|
TMPY-06355
|
Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His)
转化生长因子,TGF β1 & GARP Heterotrimer
|
Human
|
HEK293 Cells
|
|
Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 108.72 kDa and the accession number is P01137. |
|
TMPJ-00254
|
TGF beta 3 Protein, Human/Mouse/Rat, Recombinant
Latency-associated peptide,TGF-beta-3,Tran...
|
Human,Mouse,Rat
|
HEK293 Cells
|
|
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regu... |
|
TMPH-02803
|
NRROS Protein, Mouse, Recombinant (His)
|
Mouse
|
E. coli
|
|
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 acti... |
|
TMPY-04468
|
STK16 Protein, Human, Recombinant (His & NusA)
MPSK,serine/threonine kinase 16,TSF1,KRCT,...
|
Human
|
E. coli
|
|
Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is ubiquitously expressed at very low levels. STK16 / MPSK1 belongs to the protein kinase superfamily and Ser/Thr protein kinase family. It contains one protein kinase domain. Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or c... |
|
TMPY-03291
|
SMAD2 Protein, Mouse, Recombinant (His & GST)
mMad2,Smad-2,7120426M23Rik,Madr2,Madh2,SMAD family ...
|
Mouse
|
Baculovirus Insect Cells
|
|
SMAD2 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein... |
|
TMPK-00258
|
Latent TGF beta 3 Protein, Human, Recombinant (His)
TGFβ3,转化生长因子,TGF-β3,TGF-beta<...
|
Human
|
HEK293 Cells
|
|
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differentiation. And transforming growth factor beta3 (TGFbeta3) is a key protein involved in scar-free healing observed in embryos. Latent TGF beta 3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 45.9 kDa and t... |
|
TMPK-00259
|
Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
TGF-beta3,TGFβ,TGF-β,
|
Human
|
HEK293 Cells
|
|
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differentiation. And transforming growth factor beta3 (TGFbeta3) is a key protein involved in scar-free healing observed in embryos. Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predi... |
|
TMPH-03206
|
ITGB8 Protein, Rabbit, Recombinant (His & Myc)
|
Rabbit
|
E. coli
|
|
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis. ITGB8 Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli ... |
|
TMPH-02968
|
VEPH1 Protein, Mouse, Recombinant (His & Myc)
|
Mouse
|
E. coli
|
|
Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. VEPH1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.7 kDa and the accession number is A1A535. |
|
TMPJ-00271
|
SMAD3 Protein, Human, Recombinant (His & Flag)
SMAD 3,Mothers against DPP homolog 3,hMAD-3,MADH3,JV1
|
Human
|
E. coli
|
|
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated... |
|
TMPY-04203
|
RAB1B Protein, Human, Recombinant (hFc)
RAB1B, member RAS oncogene family
|
Human
|
HEK293 Cells
|
|
RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells. Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC cells in vitro and in vivo. Mechanistically, loss of RAB1B resulted in elevated expression of TGF-beta receptor 1 (TbetaR1) through decreased degradation of ubiquitin, increased levels of phosphorylated SMAD3 and TGF-beta-induced epithelial-mesenchymal transition (EMT). Furthermo... |
|
TMPH-01699
|
SMAD2 Protein, Human, Recombinant (His & SUMO)
|
Human
|
E. coli
|
|
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3... |
|
TMPK-00328
|
TGFBR2 Protein, Human, Recombinant (mFc & Avi)
TAAD2,LDS2B,LDS2,MFS2,TGFBR2,AAT3,LDS1B,
|
Human
|
HEK293 Cells
|
|
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division. TGFBR2 Protein, Human, Recombinant (mFc & Avi) is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The pred... |
|
TMPK-00329
|
TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
LDS2B,TbetaR-II,TGFβR2,LDS2,RIIC,TGF
|
Human
|
HEK293 Cells
|
|
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division. TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-mFc-Avi... |
|
TMPJ-00163
|
R-Spondin 3/RSPO3 Protein, Human, Recombinant (hFc & His)
Protein with TSP type-1 repeat,RSPO3,R-spondin-3,Ro...
|
Human
|
HEK293 Cells
|
|
R-spondin-3 (RSPO3), also known as Protein with TSP type-1 repeat, Roof plate-specific spondin-3, Thrombospondin type-1 domain-containing protein 2, PWTSR, THSD2 and CRISTIN1, is a member of the thrombospondin type 1 repeat supergene family. RSPO3 is a secreted protein and widely expressed in many tissues. RSPO3 contains two Furin-like repeats which have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases, and one TSP type-... |
|
TMPY-04422
|
Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)
CK1g2,casein kinase 1, γ2,casein kinase
|
Human
|
Baculovirus Insect Cells
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Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha, beta, gamma, and delta). Dishevelled (Dsh), another positive component of the Wnt pathway, becomes phosphorylated in response to Wnt signals. All the CKI isoforms, with the exce... |
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TMPJ-01414
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GDF-15 Protein, Mouse, Recombinant (His & Flag)
Growth Differentiation Factor 15, Macrophage inhibi...
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Mouse
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HEK293 Cells
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Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be secreted by a wide variety of cell types in response to a broad range of stressors. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenito... |
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